How Much Does Compounded Enclomiphene Cost? (2026 Price Guide)

Enclomiphene is one of the more common price-shopping requests we see from men prescribed treatment for low testosterone who want to avoid the fertility trade-off that comes with testosterone replacement. Because there is no FDA-approved enclomiphene product in the United States, every prescription is filled by a compounding pharmacy — and prices between pharmacies vary widely for the identical strength and quantity.

Here is what drives compounded enclomiphene pricing, what the prescription rules are, and one regulatory development worth understanding before you commit to a long course.

Spelling: this one trips people up

Enclomiphene is frequently mistyped. The variants we see most often are "emclomiphene", "enclomifene", "enclomiphene citratte", and "enclomiphene citrate" (the last of which is correct — citrate is the salt form).

This matters practically. Pharmacy price lists and quote systems match on the exact drug name, so a misspelling can return no results at all even when a dozen pharmacies stock the ingredient. If a search or a quote request comes back empty, check the spelling first.

Why enclomiphene is only available compounded

Enclomiphene citrate is the trans-isomer of clomiphene. Clomiphene citrate is sold as an FDA-approved product (Clomid) as a mixed-isomer 50 mg tablet, indicated for ovulation induction in women. There has never been an FDA-approved enclomiphene-only product in the U.S. — a branded version (EnCyzix) was developed but never approved.

That means a prescriber who specifically wants enclomiphene rather than clomiphene has to write it to a compounding pharmacy. FDA notes that compounded drugs are not FDA-approved, and that FDA does not verify the safety, effectiveness, or quality of a compounded preparation before it is dispensed. Background here: Compounding and the FDA: Questions and Answers.

An important regulatory caveat

Enclomiphene citrate currently sits in Category 1 of FDA's 503A bulk drug substances review — substances under evaluation, which pharmacies may compound with while the review is pending under FDA's interim enforcement policy.

However, FDA's Pharmacy Compounding Advisory Committee voted in 2022 against recommending enclomiphene for permanent inclusion on the 503A bulks list. FDA is not bound by that vote. In the years since, no final rule has been issued and enclomiphene has continued to be compounded under the interim policy — so this is a long-standing open question rather than an imminent change. But if FDA does act on the recommendation, compounding enclomiphene would no longer be permitted.

We mention this because it is directly relevant to cost decisions: it is a reason to be cautious about paying up front for a very long supply, and a reason to ask your pharmacy what their plan is if the policy changes. It is not a reason to stop a treatment your prescriber has recommended — that conversation belongs with them.

What compounded enclomiphene costs

Pricing on Compounding Finder's active pharmacy price lists clusters into two shapes, and it is worth knowing which one you are being quoted:

• Per-capsule pricing. Some pharmacies quote a unit price, commonly in the low single digits per capsule. At 12.5 mg once daily, that puts a 30-day supply at the low end of the market.
• Per-package pricing. Others quote a flat price for a 30, 45, or 90-count bottle. These are the larger numbers and are not directly comparable to a unit price until you divide.

Across active pharmacies, a 30-day supply at 12.5 mg commonly lands somewhere between roughly $40 and $150, and 25 mg between roughly $80 and $180. Ninety-day quantities usually lower the per-day cost meaningfully.

Two pharmacies can quote very different prices for the identical strength and count. Ingredient sourcing, batch size, labour model, overhead, and shipping policy all differ, and none of that is visible from the outside — which is exactly why comparing several is worth the few minutes it takes.

See current listings on the enclomiphene comparison page.

Doses seen in the clinical literature

Published trials of enclomiphene used 6.25 mg, 12.5 mg, and 25 mg daily, with the Phase III protocol starting at 12.5 mg and titrating to 25 mg if the response was insufficient. 25 mg is the highest dose studied.

We occasionally see prescriptions written well above that. We are not in a position to say whether a higher dose is appropriate for any individual — that is entirely between a patient and their prescriber — but a dose above the studied range is worth an explicit conversation, and it is also likely to be harder and more expensive to source, because fewer pharmacies list it.

Compounding Finder does not prescribe enclomiphene or advise on dosing.

What affects the price

Strength. 12.5 mg and 25 mg are the most widely stocked. Unusual strengths mean fewer pharmacies can quote, which usually means a higher price.

Quantity. A 90-day supply almost always beats three 30-day fills on a per-day basis, though see the regulatory caveat above before pre-paying for a long horizon.

Capsule versus other forms. Capsules are the standard and the cheapest. Anything else is a special order.

Combination formulations. Some pharmacies list enclomiphene combined with other ingredients. Those are priced as their own preparation and are not comparable to a plain enclomiphene capsule.

Shipping and minimums. Some pharmacies include shipping, some add a flat fee, and some have minimum order values that change the real total on a small prescription.

Prescription requirements

Enclomiphene is prescription-only. A licensed U.S. compounding pharmacy cannot dispense it without a valid prescription from a licensed prescriber, and a pharmacy that offers to ship it without one is not operating legally.

Your prescription should state the strength, the dosage form, the quantity, and the directions. If you need a specific excipient profile — dye-free, for example — that has to be written on the prescription, not requested at the counter.

Comparing quotes

Compounding Finder sends your prescription details to licensed U.S. compounding pharmacies that can fill them, and the quotes come back to you by email, usually within one to two business days. You choose which pharmacy to use, or none of them. Pricing is set by the pharmacy directly with you.

Compare compounded enclomiphene quotes →

Frequently asked questions

Is enclomiphene FDA-approved? No. There is no FDA-approved enclomiphene product in the United States. It is available only as a compounded preparation from a licensed pharmacy with a valid prescription, and compounded drugs are not FDA-approved.

Do I need a prescription for compounded enclomiphene? Yes. Any seller shipping it without a prescription is not a legitimate licensed U.S. pharmacy.

How much does enclomiphene cost per month? A 30-day supply at 12.5 mg commonly falls between roughly $40 and $150 depending on the pharmacy, with 25 mg typically higher. Comparing several licensed pharmacies is the single biggest lever on that number.

Is enclomiphene the same as clomiphene? Not quite. Enclomiphene is one isomer of clomiphene. The FDA-approved clomiphene product is a mixed-isomer 50 mg tablet indicated for ovulation induction in women, which is a different product at a different strength.

Could enclomiphene stop being available? Possibly, though nothing has changed for several years. It sits in Category 1 of FDA's 503A bulks review, and FDA's advisory committee voted against permanent inclusion in 2022. No final rule has been issued since, and it remains compoundable under FDA's interim policy. It is still worth asking your pharmacy how they would handle a policy change before pre-paying for a very long supply.

Compounding Finder is a price-comparison service, not a pharmacy and not a prescriber. We do not dispense medication or advise on treatment. Compounded drugs are not FDA-approved. Always talk to your prescriber and dispensing pharmacist about whether a compounded preparation is appropriate for you.