Compounded Enclomiphene

Ranges come from the price lists pharmacies in our network share with us for quoting, limited to pharmacies that can take your request, and they are not a quote. Shipping, dispensing fees and the exact prescription change the price; your quotes carry the real numbers and the pharmacy behind each one.

The most common indication is secondary hypogonadism in men — confirmed low testosterone with low or inappropriately normal LH/FSH — where the prescriber wants to raise endogenous testosterone without suppressing fertility. Enclomiphene stimulates the hypothalamus to release GnRH, which drives LH/FSH production and, in turn, testicular testosterone synthesis.

It's also prescribed as a TRT alternative for men who want to preserve fertility, as an adjunct to TRT to maintain testicular size and function, and as part of post-cycle therapy (PCT) to restart natural testosterone production after exogenous testosterone use. Dosing is typically 12.5–25 mg daily, with lab monitoring of testosterone, LH, FSH, and estradiol every 3 months.

Commercial clomiphene citrate (Clomid) is a racemic mixture — approximately 62% enclomiphene (trans) and 38% zuclomiphene (cis). The enclomiphene fraction is responsible for the testosterone-raising effect; the zuclomiphene fraction is a longer-acting estrogen agonist that some patients tolerate poorly (mood changes, visual disturbances, elevated estradiol).

Compounded enclomiphene is the pure trans-isomer — same testosterone-raising effect without the cis-isomer side effects. It's particularly preferred by clinicians whose patients have previously had mood or estrogenic side effects on Clomid. Clomid is FDA-approved for female infertility; enclomiphene monotherapy is not FDA-approved and is prescribed off-label for male secondary hypogonadism.

Compounding pharmacies typically prepare enclomiphene as oral capsules at custom strengths. The most common strengths are 6.25 mg, 12.5 mg, and 25 mg. Typical dosing for male secondary hypogonadism is 12.5 mg daily, titrated up to 25 mg daily if testosterone response is inadequate after 6 weeks.

Protocols vary — some clinicians use alternating-day dosing (25 mg every other day) or 5-days-on/2-days-off patterns to minimize cumulative side effects. Lab monitoring typically includes total and free testosterone, LH, FSH, estradiol, SHBG, and CBC every 3 months during titration.

Compounded enclomiphene capsules typically run $50–$120 for a 30-day supply at standard 12.5 mg or 25 mg daily dosing. Pricing varies by strength and quantity.

Generic clomiphene (not enclomiphene) is often dramatically cheaper but delivers the racemic mixture with more side effects. Clinicians who specifically prescribe enclomiphene have weighed this tradeoff for the individual patient. Prices for the same prescription can differ widely between pharmacies, so it is worth comparing quotes.

Prices for the same compounded prescription often differ widely between pharmacies — on almost half of the requests we compared (all medications combined), the highest quote was at least double the lowest. Factors that affect pricing include the pharmacy’s location, their ingredient sourcing, and compounding volume.

By comparing quotes from multiple licensed pharmacies, you can find the best combination of price, quality, and convenience without spending hours making phone calls.