How Much Does Compounded Progesterone Cost? (2026 Price Guide)

Progesterone is one of the highest-volume compounding requests in the country, and one where the price you pay depends almost entirely on which form you were prescribed. A capsule, a topical cream, and a vaginal suppository are three different products with three different price structures.

Why progesterone gets compounded

Micronised progesterone is available commercially as Prometrium and its generics, in fixed capsule strengths. Compounding is used when a prescriber needs something that product cannot provide:

A strength that does not exist commercially. Prometrium comes in set strengths; a prescriber titrating outside them needs a compounded capsule.

A different route. There is no commercial topical progesterone cream or compounded-equivalent vaginal suppository at arbitrary strengths. Those forms only come from a compounding pharmacy.

Excipient control. Commercial micronised progesterone capsules are formulated in peanut oil. For a patient with a peanut allergy that is disqualifying, and a compounded preparation in a different carrier is the alternative.

Whether a compounded preparation is appropriate is a decision for your prescriber. Compounding Finder does not prescribe progesterone or advise on hormone therapy. FDA notes compounded drugs are not FDA-approved — see Compounding and the FDA.

What compounded progesterone costs

Progesterone has the deepest price-list coverage of any compound we track — several hundred priced rows across active pharmacies — so these figures are better grounded than most.

Quotes commonly fall between roughly $25 and $125, with the median near $95 for a typical fill.

By form, in the order patients request them:

• Capsules — the most requested, and generally the most economical per month.
• Topical cream — priced by total grams at a stated concentration; compare cost per month of use, not per jar.
• Vaginal suppositories — priced by count and strength; typically the highest per-dose of the three.

See current listings on the progesterone comparison page.

Compare like for like

Progesterone quotes are unusually easy to compare wrongly, because the same drug name covers very different preparations:

Capsule quotes are per count at a strength. A 100-count bottle at 100 mg and a 30-count at 200 mg are not the same purchase.

Cream quotes are per total grams at a concentration. Ask how many grams your prescribed daily dose uses, then divide.

Suppository quotes are per count. Straightforward, but rarely comparable to either of the above.

If you are comparing a compounded capsule against commercial Prometrium, check your insurance first — if the commercial product is covered for you, it may well be the cheaper option. Compounded preparations are usually cash-pay.

What affects the price

Form. The largest single factor, as above.

Strength and quantity. Larger fills lower cost per day. Unusual strengths narrow the field of pharmacies.

Base or carrier. A specified non-peanut-oil carrier, or a particular cream base, changes both price and which pharmacies will take it. If you need this, it belongs on the prescription.

Combination formulations. Progesterone is frequently compounded with estradiol or as part of a bi-est or tri-est preparation. Those are priced as their own preparation and are not comparable to plain progesterone.

Shipping and minimums. Meaningful on a single small order.

Prescription requirements

Progesterone is prescription-only. Your prescription should state the form, the strength, the total quantity, the carrier or base if it matters to you, and the directions.

Comparing quotes

Compare compounded progesterone quotes →

Quotes come back by email, usually within one to two business days. You choose the pharmacy, and pricing is set by the pharmacy directly with you.

Frequently asked questions

How much does compounded progesterone cost per month? Most quotes fall between roughly $25 and $125, median near $95 — but the form drives most of that. Capsules are typically the lowest, suppositories the highest per dose.

Is compounded progesterone cheaper than Prometrium? Not necessarily. If Prometrium or its generic is covered by your insurance, that is often the cheaper route. Compounded progesterone is usually cash-pay, and its advantage is the strength, route, or carrier — not automatically the price.

Why would I need compounded progesterone instead of the commercial capsule? Common reasons are a strength that does not exist commercially, a route that does not exist commercially (cream, suppository), or a peanut allergy — commercial micronised progesterone capsules are formulated in peanut oil. Your prescriber decides.

Can it be combined with estradiol? Yes, and it commonly is. That is a single compounded preparation priced on its own terms.

Do I need a prescription? Yes.

Compounding Finder is a price-comparison service, not a pharmacy and not a prescriber. We do not dispense medication or advise on treatment. Compounded drugs are not FDA-approved. Always talk to your prescriber and dispensing pharmacist about whether a compounded preparation is appropriate for you.