HomeDrug ClassesPDE5 Inhibitors

PDE5 Inhibitors

Phosphodiesterase type 5 inhibitors — sildenafil, tadalafil, vardenafil — used for erectile dysfunction and, in some cases, pulmonary hypertension.

About PDE5 Inhibitors

PDE5 inhibitors block the enzyme that breaks down cGMP, promoting smooth muscle relaxation and blood flow. Commercial tablets (Viagra, Cialis, Levitra and their generics) are well-established, but compounding pharmacies prepare sildenafil, tadalafil, and vardenafil as troches, rapid-dissolve tablets, and liquid suspensions — useful for patients with dysphagia, unusual doses (e.g., daily low-dose tadalafil), or combination preparations. Patients who do not respond adequately to oral PDE5 inhibitors may be prescribed compounded injection therapy (trimix, bimix) instead.

Medications in This Class

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Sildenafil

Compounded sildenafil is a PDE5 inhibitor prescribed primarily for erectile dysfunction (ED) and pulmonary arterial hype...

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Tadalafil

Compounded tadalafil is a long-acting PDE5 inhibitor prescribed for erectile dysfunction (ED) and benign prostatic hyper...

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Vardenafil

Compounded vardenafil offers the same active ingredient as Levitra at a dramatically lower cost — with a faster onset an...

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Trimix

Trimix is the most effective treatment for erectile dysfunction when pills have failed — a compounded 3-drug injectable ...

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Bimix

Bimix is a 2-drug compounded intracavernosal injectable for ED — the preferred alternative for men who experience pain w...

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Conditions Treated with PDE5 Inhibitors

Erectile Dysfunction
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Sexual Dysfunction
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This information is for informational purposes only and is not meant to be a substitute for professional medical advice, diagnosis or treatment. Compounding Finder is not offering advice, recommending or endorsing any specific prescription drug, pharmacy or other information. Please seek medical advice before starting, changing or terminating any medical treatment.