PDE5 (phosphodiesterase type 5) inhibitors relax smooth muscle and increase blood flow by blocking the PDE5 enzyme. While associated with erectile dysfunction, compounded PDE5 inhibitors are also used for pulmonary hypertension, female sexual dysfunction, and Raynaud's phenomenon.
PDE5 inhibitors block the breakdown of cGMP in smooth muscle cells. Elevated cGMP causes vasodilation and smooth muscle relaxation in vascular and erectile tissues, increasing blood flow on demand.
Brand-name sildenafil and tadalafil are expensive. Compounding provides cost-effective alternatives in customized doses, combination formulations (e.g., tadalafil + oxytocin), topical creams for female use, and troches for faster absorption.
Compounded sildenafil and tadalafil are not FDA-approved as finished products but are legally compounded on prescription. They are not permitted on FDA's 503B bulk compounding lists for outsourcing facilities. Patients should disclose cardiovascular history as PDE5 inhibitors are contraindicated with nitrates.
These compounded medications belong to this drug class. Click any medication to learn more and compare pharmacy prices.
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