Growth hormone secretagogues (GHS) stimulate the pituitary gland to naturally release growth hormone (GH). Unlike synthetic HGH injections, GHS peptides work physiologically through the body's own feedback mechanisms, making them popular in anti-aging and functional medicine.
Sermorelin and CJC-1295 mimic GHRH (growth hormone releasing hormone) and bind to GHRH receptors on the pituitary. Ipamorelin and GHRP-6 mimic ghrelin and activate GH secretagogue receptors. Together they produce a synergistic GH pulse that stimulates IGF-1 production in the liver.
Growth hormone secretagogue peptides are not FDA-approved as finished drug products and are exclusively available through 503A compounding pharmacies by prescription. They cannot be purchased OTC or from commercial manufacturers.
Growth hormone secretagogue peptides are compounded under 503A for patient-specific prescriptions. The FDA has restricted several peptides including GHRP-2, GHRP-6, and CJC-1295 from use in compounding in 2023. Tesamorelin is FDA-approved for HIV-associated lipodystrophy. Verify availability with your pharmacy as the regulatory landscape for peptides continues to evolve.
These compounded medications belong to this drug class. Click any medication to learn more and compare pharmacy prices.
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