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GHK-Cu binds to copper ions and activates a broad gene expression program including collagen and elastin synthesis, antioxidant enzymes, hair follicle stimulation, and anti-inflammatory pathways — acting as a biological reset signal that reverses aging gene expression patterns.
GHK-Cu for injectable and prescription-strength topical use is available only through compounding pharmacies. OTC cosmetic GHK-Cu products contain negligible concentrations insufficient for therapeutic effect.
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GHK-Cu (Glycyl-L-Histidyl-L-Lysine copper complex) is a naturally occurring human tripeptide first isolated from serum. Levels are highest in youth and decline with age — correlating with reduced wound healing capacity, collagen loss, and hair follicle miniaturization.
Dr. Loren Pickart's research demonstrated that GHK-Cu influences the expression of over 4,000 human genes — effectively reversing gene expression patterns associated with aging toward those of younger tissue. This makes it one of the broadest-acting bioregulatory compounds available.
Anti-aging (skin collagen stimulation, wrinkle reduction), wound healing, hair loss (stimulates follicle stem cells), post-procedure skin repair, general longevity protocols
Injectable (SubQ): 1–2mg/day for anti-aging protocols
Topical (1–2%): Apply to face or scalp 1–2x daily
Scalp solution: 0.1–0.5% applied to scalp with or without minoxidil
Excellent safety profile — GHK-Cu is a naturally occurring human peptide. Topical: mild irritation at high concentrations. Injectable: injection site reactions. Skin darkening at application sites has been reported at very high doses.
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