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MK-677 is a non-peptide ghrelin receptor agonist that orally stimulates GH release from the pituitary in a sustained, pulsatile pattern — raising IGF-1 by 40–79% in clinical trials without suppressing the HPG axis or causing adrenal suppression.
MK-677 is not FDA-approved. Compounding pharmacies provide pharmaceutical-grade oral capsules as the only legitimate source for therapeutic use — avoiding the unregulated research chemical market.
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MK-677 (Ibutamoren mesylate) is a selective, orally active ghrelin receptor (GHSR) agonist that mimics ghrelin to stimulate sustained GH and IGF-1 secretion. Unlike injectable GHRP/GHRH peptides requiring multiple daily injections, MK-677 is taken once daily orally — making it the most convenient GH secretagogue available.
Multiple clinical trials demonstrate that MK-677 raises IGF-1 by 40–79%, increases lean muscle mass, reduces fat mass, improves bone mineral density, and enhances slow-wave sleep — the stage when most GH is naturally released. It is used in longevity, body composition, and sleep optimization protocols.
GH and IGF-1 optimization, muscle mass building, fat loss, bone density (elderly), deep sleep enhancement, recovery from muscle wasting conditions
Standard: 12.5–25mg orally once daily at bedtime
Allow 3–6 months for full body composition effects. Monitor IGF-1 at 3 months.
Increased appetite (ghrelin effect — most common), water retention (first 2–4 weeks), lethargy at initiation, transient blood sugar elevation. Monitor fasting glucose, especially in pre-diabetic patients.
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