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Ipamorelin is a GHRP (growth hormone releasing peptide) that stimulates GH release from the pituitary. CJC-1295 is a GHRH analog that amplifies and prolongs that GH pulse. Together they produce significantly greater and more sustained GH release than either peptide alone.
Neither Ipamorelin nor CJC-1295 has an FDA-approved commercial equivalent. Licensed compounding pharmacies are the only legal source for these peptides in the US.
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Ipamorelin and CJC-1295 are two complementary peptides that work on different steps of the growth hormone secretion pathway — producing a synergistic effect when combined.
Ipamorelin is a selective growth hormone secretagogue that mimics ghrelin, binding to GHSR receptors in the pituitary to trigger GH release. It is considered one of the cleanest GHRPs available — producing minimal cortisol, prolactin, or appetite stimulation compared to older peptides like GHRP-2 or GHRP-6.
CJC-1295 is a modified GHRH analog that extends the half-life of natural GHRH from minutes to days (with DAC — drug affinity complex), providing a sustained background elevation in GH pulsatility. Combined with Ipamorelin, it produces GH pulses that mimic youthful secretion patterns.
Ipamorelin — GHSR Agonism
Ipamorelin binds to the ghrelin receptor (GHSR-1a) on pituitary somatotrophs, triggering GH release in a pulsatile, dose-dependent manner without significantly affecting cortisol, prolactin, or ACTH.
CJC-1295 — GHRH Receptor Agonism
CJC-1295 binds to GHRH receptors on the pituitary, amplifying GH synthesis and release. The DAC version binds to albumin in plasma, extending its half-life to 6–8 days and producing a sustained elevation in baseline GH.
Synergistic Effect
GHRH (CJC-1295) and GHRP (Ipamorelin) act on different receptors and through different mechanisms — when combined, GH release is 2–4x greater than either peptide alone.
Anti-aging / Longevity: Age-related GH decline, body composition, skin quality, bone density
Fat Loss: Visceral fat reduction, metabolic optimization
Muscle Recovery: Post-workout recovery, lean mass preservation
Sleep: Deep sleep enhancement (GH is primarily released during slow-wave sleep)
Injury Recovery: Accelerated healing, collagen synthesis
Standard protocol: 100–300mcg Ipamorelin + 100–300mcg CJC-1295 SubQ, injected together nightly at bedtime
Advanced (twice daily): Morning and bedtime injections for accelerated results
Nightly dosing leverages the body's natural overnight GH pulse. Allow 3–6 months for meaningful body composition changes. IGF-1 levels can be monitored to assess response.
Start at the lower end (100mcg each) for the first 2–4 weeks to assess tolerance. Some water retention is common initially as GH levels rise — this typically resolves. Cycle 5 days on, 2 days off to prevent receptor desensitization. IGF-1 monitoring at 3 months helps optimize dosing.
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