Drug Classes

Immunomodulator Drug Class

Immunomodulators regulate the immune system — either suppressing overactive immune responses in autoimmune disease or enhancing immune function in immunodeficiency. Compounded immunomodulators include Low Dose Immunotherapy (LDI), thymosin peptides, and immune-regulating compounds used in integrative medicine.

How It Works

Depending on the agent, immunomodulators work by desensitizing the immune system to specific antigens (LDI), stimulating T-cell maturation (thymosin alpha-1), blocking inflammatory cytokines, or modulating toll-like receptors (LDN dual-mechanism).

Why Compounded?

Low Dose Immunotherapy (LDI) requires ultra-dilute preparations of specific antigens compounded by specialized pharmacies. Thymosin peptides, BPC-157, and other immunomodulating peptides are only available through compounding pharmacies.

Common Uses

  • Mast Cell Activation Syndrome (MCAS)
  • Lyme disease and co-infections
  • Food and chemical sensitivities
  • Autoimmune conditions (Hashimoto's, lupus, RA)
  • Post-viral immune dysregulation
  • Cancer immune support
  • Chronic fatigue and fibromyalgia

Common Compounded Medications

  • Low Dose Immunotherapy (LDI) Antigens
  • Thymosin Alpha-1 Injection
  • Thymosin Beta-4 (TB-500)
  • BPC-157 Capsules or Injection
  • Low Dose Naltrexone (LDN) — dual immunomodulator

Regulatory & Safety Notes

Immunomodulating peptides like thymosin alpha-1 and BPC-157 are not FDA-approved for general use and are compounded under 503A for patient-specific prescriptions. The FDA has issued guidance restricting certain peptides from compounding. Verify availability with your pharmacy before prescribing.

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