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LL-37 is a host defense peptide that disrupts microbial cell membranes (broad-spectrum antimicrobial), stimulates immune cell recruitment and function, promotes tissue repair and angiogenesis, and modulates the inflammatory response — serving as a bridge between innate and adaptive immunity.
LL-37 has no FDA-approved commercial equivalent. Compounding pharmacies are the only legal source for therapeutic LL-37 injectable preparations.
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LL-37 (cathelicidin antimicrobial peptide) is a 37-amino acid human host defense peptide produced by neutrophils, macrophages, NK cells, and epithelial cells at sites of infection and injury. It is the only cathelicidin in the human genome and serves as a critical front-line defense against microbial invasion.
Beyond antimicrobial activity, LL-37 has been found to modulate immune responses, promote wound healing, and stimulate angiogenesis. Low LL-37 levels have been associated with atopic dermatitis, lupus, inflammatory bowel disease, and increased susceptibility to infections.
Chronic infections (antibiotic-resistant or recurrent), biofilm-related infections, wound healing, immune deficiency states, atopic dermatitis (topical), Long COVID immune support
SubQ: 100–500mcg daily or as directed by provider
Topical: 0.01–0.1% cream applied to wounds or affected skin 2–3x daily
Injectable: injection site reactions, transient inflammatory response, fatigue. Topical: mild irritation. Generally well tolerated at therapeutic doses.
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