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Selank is a synthetic analog of tuftsin with GABA-A modulatory effects, BDNF upregulation, and serotonin/dopamine normalization — reducing anxiety, improving cognitive function, and modulating the immune response without the receptor downregulation of classic benzodiazepines.
Selank has no FDA-approved commercial equivalent. Compounding pharmacies are the only legal domestic source for Selank nasal spray and injectable preparations.
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Selank is a heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) developed and approved in Russia for anxiety and asthenic disorders. It was designed as a synthetic analog of tuftsin — an endogenous peptide involved in immune regulation — with additional modifications to extend duration of action.
Selank produces anxiolytic effects through GABA-A modulation and normalizes neurotransmitter ratios (serotonin, dopamine, norepinephrine) disrupted by chronic stress. Unlike benzodiazepines, it does not cause sedation, memory impairment, or dependence — making it highly attractive for professionals and patients who need anxiety control without functional compromise.
Generalized anxiety disorder, social anxiety, PTSD, cognitive enhancement under stress, immune modulation, depression adjunct
Intranasal spray: 250–750mcg per nostril 2–3x daily
Injectable: 250–500mcg SubQ once or twice daily
Excellent tolerability. Mild sedation at higher doses, nasal irritation with spray. No dependence or withdrawal effects reported. Slight fatigue at initiation.
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