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Rapamycin inhibits mTOR complex 1, a key regulator of cell growth, metabolism, and aging. By inhibiting mTOR, it activates autophagy, reduces cellular senescence, and mimics effects of caloric restriction. At low longevity doses (typically 2–10mg once weekly), immunosuppression is minimal.
Commercial Rapamune is expensive and available only in 1mg tablets. Compounding pharmacies prepare custom dose capsules (0.5–5mg), combination longevity formulations, and topical preparations for skin rejuvenation at significantly lower cost.
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Rapamycin is the most studied longevity compound in animal models, extending lifespan in mice even when started late in life. Human longevity use is led by physicians like Dr. Peter Attia. Compounded low-dose weekly rapamycin has become one of the most requested longevity medications at specialized compounding pharmacies.
Longevity and anti-aging protocols, organ transplant immunosuppression (brand), age-related macular degeneration (investigational), topical skin rejuvenation.
Longevity protocol: 2–10mg once weekly (most common off-label use). Topical: 0.1–1% cream applied to face. Always under physician supervision.
Mouth sores/aphthous ulcers (most common at higher doses), mild immunosuppression, elevated triglycerides/cholesterol, impaired wound healing. Side effects are significantly reduced at low weekly longevity doses.
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