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Antihistamines (H1 & H2)

H1 and H2 receptor blockers used for allergy, MCAS, chronic urticaria, and related histamine-driven conditions — compounded dye-free for sensitive patients.

About Antihistamines

Antihistamines block histamine at H1 receptors (cetirizine, hydroxyzine, diphenhydramine, azelastine) or H2 receptors (famotidine). Cyproheptadine is a first-generation H1 blocker with additional antiserotonergic activity. In MCAS and CIRS protocols, H1 and H2 antihistamines are typically layered together and often combined with mast cell stabilizers. Compounding is frequently requested because many MCAS patients react to commercial tablet coatings, dyes, and fillers. Licensed 503A compounding pharmacies can prepare these drugs in dye-free, filler-minimized capsules, liquids, and transdermal creams.

Medications in This Class

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Cetirizine

Cetirizine is a second-generation H1 antihistamine used for allergies, chronic hives, and mast cell activation syndrome ...

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Hydroxyzine

Hydroxyzine is a first-generation H1 antihistamine prescribed for anxiety, allergies, and pruritus. Compounded dye-free ...

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Diphenhydramine

Diphenhydramine (Benadryl) is a first-generation H1 antihistamine available in compounded formulations including dye-fre...

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Azelastine

Azelastine is a second-generation H1 antihistamine primarily used as a nasal spray and eye drops for allergic rhinitis a...

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Cyproheptadine

Cyproheptadine is a first-generation H1 antihistamine with additional antiserotonergic properties. It is commonly compou...

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Famotidine

Famotidine is an H2 histamine blocker commonly used for acid reflux, peptic ulcers, and as part of mast cell activation ...

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Conditions Treated with Antihistamines

MCAS (Mast Cell Activation Syndrome)
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CIRS / Mold Illness
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This information is for informational purposes only and is not meant to be a substitute for professional medical advice, diagnosis or treatment. Compounding Finder is not offering advice, recommending or endorsing any specific prescription drug, pharmacy or other information. Please seek medical advice before starting, changing or terminating any medical treatment.