Mast cell stabilizers prevent mast cells from releasing histamine and other inflammatory mediators. In compounded form, they are critical for patients with Mast Cell Activation Syndrome (MCAS) and mastocytosis who need customized dosing or delivery forms.
Mast cell stabilizers like cromolyn sodium and ketotifen inhibit degranulation of mast cells, preventing the release of histamine, leukotrienes, prostaglandins, and tryptase that trigger allergic and inflammatory cascades.
Cromolyn sodium oral solution is commercially available but expensive and limited in concentration. Ketotifen is only available in the US as eye drops. Compounding enables oral ketotifen capsules, liquid suspensions, nasal sprays, and topical formulations at therapeutic doses.
Ketotifen is not FDA-approved in the US for systemic use (only as an ophthalmic solution). Oral ketotifen is commonly compounded for MCAS treatment. Cromolyn sodium oral solution (Gastrocrom) is FDA-approved but expensive; compounded versions are cost-effective alternatives. Prescriptions are required.
These compounded medications belong to this drug class. Click any medication to learn more and compare pharmacy prices.
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