Adrenal hormones including DHEA (dehydroepiandrosterone) and cortisol are produced by the adrenal cortex. DHEA is a precursor to testosterone and estrogen, while cortisol regulates the stress response and immune function. Compounded adrenal hormones are used in adrenal insufficiency, BHRT, and autoimmune conditions.
DHEA is peripherally converted to testosterone and estrogen in tissues. It also acts directly on GABA receptors as a neurosteroid. Cortisol (hydrocortisone) binds to glucocorticoid receptors, regulating inflammation, glucose metabolism, and the stress response.
Therapeutic-dose DHEA beyond OTC supplements, low-dose physiologic cortisol (hydrocortisone), DHEA vaginal suppositories, and customized adrenal support preparations all require compounding.
DHEA is classified as a dietary supplement at OTC doses but requires a prescription in compounded therapeutic formulations. Cortisol (hydrocortisone) compounded at physiologic doses is prescribed for adrenal insufficiency. Patients should undergo appropriate adrenal function testing before beginning therapy.
These compounded medications belong to this drug class. Click any medication to learn more and compare pharmacy prices.
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