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Pregnenolone is the biosynthetic precursor to all steroid hormones, converted from cholesterol in the mitochondria. It can convert to DHEA, progesterone, cortisol, testosterone, and estrogens — making it a foundational hormone optimization compound. It also has direct neurosteroid activity at GABA-A, NMDA, and sigma-1 receptors.
OTC pregnenolone supplements have variable quality and potency. Prescription compounded pregnenolone provides pharmaceutical-grade purity, custom doses outside commercial OTC ranges, and specialized delivery methods.
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Pregnenolone is the 'mother of all steroid hormones' — the foundational precursor synthesized from cholesterol in the adrenal glands, gonads, and brain that serves as the starting point for the entire steroid hormone cascade. Levels decline with age and chronic stress, contributing to reduced hormone output across multiple pathways.
Beyond its role as a hormone precursor, pregnenolone is a neurosteroid with direct effects on memory, mood, and neuroprotection through activity at GABA-A (anxiolytic), NMDA, and sigma-1 receptors. It is one of the most abundant steroids in the human brain.
Prescription compounded pregnenolone is used in comprehensive hormone optimization protocols, adrenal fatigue management, cognitive support, and mood regulation.
Hormone optimization (BHRT foundational support), cognitive enhancement (memory and mood), adrenal support, fatigue, depression adjunct, arthritis (anti-inflammatory neurosteroid effects)
Typical range: 10–100mg daily orally
Dose based on clinical assessment and serum pregnenolone levels if available. Start at 10–25mg and adjust.
Generally well tolerated. Mild acne, irritability, insomnia, headache at higher doses. As a precursor, its effects depend on individual conversion pathways — monitor downstream hormones (DHEA-S, testosterone, estradiol) with higher doses.
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