Low Dose Naltrexone (LDN) has become one of the most widely prescribed compounded medications in the U.S. — used for autoimmune conditions, MCAS, fibromyalgia, Crohn's disease, and more. But if you've ever tried to find out what it costs before you fill your prescription, you've probably run into a wall of "call for pricing."

Here's what LDN actually costs, based on real quotes from licensed compounding pharmacies.

What Is Compounded LDN?

LDN is naltrexone — an FDA-approved opioid antagonist — prescribed at very low doses (typically 1.5mg to 4.5mg) far below the standard 50mg dose used for opioid use disorder. At these micro-doses, naltrexone appears to modulate the immune system and endorphin production rather than block opioids. Because 1.5–4.5mg doses are not commercially available, LDN must be compounded by a licensed pharmacy. Learn more on the LDN Research Trust.

LDN Price Ranges by Form

Based on real quotes collected through CompoundingFinder:

• Oral capsules (30-count): $25–$65/month — most common form
• Oral liquid (30ml, 5mg/ml): $45–$85/month — allows precise dose titration
• Nasal spray: $55–$95/month — for patients who prefer intranasal delivery
• Topical cream/gel: $40–$80/month — less common, used for localized conditions

See full pricing details on our LDN medication page.

Prices vary significantly between pharmacies — sometimes by 2–3x for the identical formulation. A pharmacy charging $85/month for LDN capsules and one charging $35/month may be compounding the exact same product.

What Affects the Price?

Strength and concentration. Higher concentrations affect the volume needed and sometimes the price.

Form. Capsules are generally the most economical. Oral liquid costs more. Nasal sprays typically cost the most.

Excipient choices. Patients with MCAS, gluten sensitivity, or dye allergies may need specific inactive ingredient specifications — this can add to cost.

Quantity. A 90-day supply is often significantly cheaper per-unit than a 30-day supply.

Shipping. Many compounding pharmacies ship nationwide. Shipping costs range from $0–$25 depending on the pharmacy and method.

Why Are LDN Prices So Variable?

Unlike mass-manufactured drugs, compounded medications are prepared in smaller batches by individual pharmacies. Each pharmacy sets its own pricing based on overhead, ingredient costs, labor, and margin. There's no standardized price list. To understand more about how this works, read our guide on how compounding pharmacies work.

How to Get the Best Price on LDN

The most effective way to find the best LDN price is to collect quotes from multiple pharmacies at once. You can call pharmacies individually (time-consuming), ask your prescriber (they may have a preferred pharmacy, but it may not be the most affordable), or use a free comparison service like CompoundingFinder.com, which sends your quote request to multiple licensed pharmacies and returns prices side-by-side within 1–2 business days.

Does Insurance Cover Compounded LDN?

Usually not. Most commercial insurance plans do not cover compounded medications, including LDN. FSA and HSA funds can typically be used for compounded prescriptions with a valid prescription from your provider. For more on what drives these costs, see our compounding pharmacy explainer.

Bottom Line

Compounded LDN costs $25–$95/month depending on form, strength, and the pharmacy you use. Given the price variation, comparing quotes before filling is one of the easiest ways to reduce your monthly medication spend. Get your free LDN price comparison →