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Prevents mast cells from degranulating — stopping the release of histamine, leukotrienes, and other inflammatory mediators before they trigger symptoms.
Blocks histamine H1 receptors directly at target tissues — a second line of action that manages symptoms even when some mediator release occurs.
Compounded omeprazole oral paste for horses treats and prevents gastric ulcers at a fraction of the cost of GastroGard, making long-term equine ulcer management financially practical.
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Omeprazole irreversibly inhibits the hydrogen-potassium ATPase enzyme in gastric parietal cells, suppressing acid secretion and allowing ulcer healing.
GastroGard (commercial omeprazole paste) is expensive, often exceeding $40 per dose. Compounded omeprazole paste provides a significantly more cost-effective treatment option.
Equine gastric ulcer syndrome (EGUS) is extremely common in horses, affecting up to 90% of racehorses and 60% of performance horses. GastroGard (omeprazole paste) is the only FDA-approved treatment, but at $40–60 per dose tube, a standard 28-day treatment course can cost $1,100–1,700 — a significant barrier to treatment and prevention.
Compounded omeprazole paste is prepared by licensed compounding pharmacies at substantially lower cost, making it practical for both treatment and maintenance (prevention) protocols. While the FDA has noted concerns about bioequivalence of some compounded formulations, many horse owners and veterinarians use compounded omeprazole successfully with appropriate dosing adjustments.
Omeprazole is a proton pump inhibitor (PPI) that irreversibly binds to and inhibits the hydrogen-potassium ATPase enzyme (the proton pump) in gastric parietal cells. This prevents acid secretion at the final step in the acid production pathway, producing a sustained and profound reduction in gastric acid output.
Acid suppression allows healing of existing ulcers and prevents new ulcer formation in high-risk horses.
Compounded omeprazole paste is used in horses for treatment of gastric ulcers (EGUS) and as maintenance/prevention therapy in horses at high risk due to intensive exercise, NSAIDs, stress, or housing conditions. It targets squamous (non-glandular) gastric ulcers most effectively.
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⚠️ Dosing should be determined by your prescriber. The information below is general guidance only.
Omeprazole is generally very well tolerated in horses. Long-term acid suppression may theoretically affect calcium absorption and microbiome balance in the hindgut, but clinically significant adverse effects at standard doses are uncommon.
Some horses on long-term PPI therapy may develop rebound acid hypersecretion if the medication is stopped abruptly; gradual tapering is recommended after treatment courses.
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Prevents mast cells from degranulating — stopping the release of histamine, leukotrienes, and other inflammatory mediators before they trigger symptoms.
