Find the lowest price from 7,500+ FDA-registered pharmacies. Save up to 90%.
⭐ 4.7/5 Customer Rating
🏅 FDA-Registered Pharmacies
Prevents mast cells from degranulating — stopping the release of histamine, leukotrienes, and other inflammatory mediators before they trigger symptoms.
Blocks histamine H1 receptors directly at target tissues — a second line of action that manages symptoms even when some mediator release occurs.
Cyproheptadine is a first-generation H1 antihistamine with additional antiserotonergic properties. It is commonly compounded for appetite stimulation, migraine prevention, cyclic vomiting syndrome, and mast cell conditions in both adults and children.
Search 7,500+ licensed pharmacies to find the best value, closest location, and fastest turnaround for
.
Cyproheptadine blocks both H1 histamine receptors and serotonin (5-HT2A) receptors. This dual mechanism provides antihistamine effects for allergic conditions while its antiserotonergic action stimulates appetite, reduces migraine frequency, and helps manage serotonin-related symptoms.
Commercial cyproheptadine (Periactin) has been discontinued by many manufacturers, making compounded versions essential. Compounding also allows pediatric-friendly liquid formulations, custom low doses for sensitive patients, and dye-free or filler-free preparations for patients with MCAS or chemical sensitivities.
Cyproheptadine is a unique first-generation antihistamine that combines H1 receptor blockade with potent serotonin antagonism. Originally developed for allergic conditions, it has become widely used off-label for appetite stimulation in underweight patients, migraine prophylaxis, and cyclic vomiting syndrome — particularly in pediatric populations.
With the commercial product (Periactin) increasingly difficult to find, compounding pharmacies have become a primary source for cyproheptadine. This is especially important for children who need flavored liquid formulations and for MCAS patients who require excipient-free preparations.
BIND THIS TO: Mechanism Text CMS field (Rich Text). Then delete this paragraph and add a Rich Text element instead.
⚠️ Dosing should be determined by your prescriber. The information below is general guidance only.
Submit a quote request to find the lowest price. Quotes delivered to your inbox.
Find Lowest Price.png){kind=spacer}
Prevents mast cells from degranulating — stopping the release of histamine, leukotrienes, and other inflammatory mediators before they trigger symptoms.
