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Prevents mast cells from degranulating — stopping the release of histamine, leukotrienes, and other inflammatory mediators before they trigger symptoms.
Blocks histamine H1 receptors directly at target tissues — a second line of action that manages symptoms even when some mediator release occurs.
Compounded clomipramine chewable treats make this tricyclic antidepressant easy to give daily — with precise weight-based doses and palatable flavors for dogs with separation anxiety and compulsive behaviors.
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Clomipramine is a tricyclic antidepressant that inhibits reuptake of serotonin and norepinephrine, reducing anxiety and compulsive behaviors.
Commercial clomipramine tablets require splitting for small dogs and are difficult to administer. Compounded chewable treats in chicken or beef flavor improve daily compliance.
Clomipramine is a tricyclic antidepressant (TCA) approved for canine separation anxiety under the brand name Clomicalm. It is also used off-label for obsessive-compulsive behaviors, noise phobias, and generalized anxiety. The commercial product is available in 5mg, 20mg, 40mg, and 80mg tablets, but these sizes are limiting for small dogs who require intermediate doses.
Compounded clomipramine chewable treats provide precise milligram dosing in any strength, with flavoring that makes daily administration enjoyable for the dog. This is especially important for behavioral medications, as consistent daily dosing is essential for therapeutic effect.
Clomipramine inhibits the reuptake of both serotonin and norepinephrine at presynaptic nerve terminals, increasing the availability of both neurotransmitters in the synapse. It also has anticholinergic, antihistaminic, and alpha-adrenergic blocking properties.
The serotonergic component is primarily responsible for its anti-anxiety and anti-compulsive effects, while the noradrenergic component contributes to its overall behavioral modulatory activity.
Compounded clomipramine chewables are used in dogs for separation anxiety (the primary FDA-approved indication), obsessive-compulsive disorder (acral lick dermatitis, tail chasing, fly-snapping), and various anxiety-related behavioral disorders. It is often used alongside behavior modification protocols.
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⚠️ Dosing should be determined by your prescriber. The information below is general guidance only.
Common side effects include sedation, dry mouth, and mild gastrointestinal upset (vomiting, constipation) during the first weeks of therapy. Most dogs adapt to these effects over time.
Clomipramine should be used cautiously with other medications due to potential drug interactions. It is contraindicated within 14 days of MAO inhibitor use. Overdose can cause cardiac arrhythmias — keep safely stored away from pets.
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Prevents mast cells from degranulating — stopping the release of histamine, leukotrienes, and other inflammatory mediators before they trigger symptoms.
