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Prevents mast cells from degranulating — stopping the release of histamine, leukotrienes, and other inflammatory mediators before they trigger symptoms.
Blocks histamine H1 receptors directly at target tissues — a second line of action that manages symptoms even when some mediator release occurs.
Cisapride oral suspension is only available through compounding pharmacies and is the most effective motility agent for cats with megacolon, chronic constipation, and GI motility disorders.
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Cisapride enhances GI motility by stimulating serotonin receptors in the enteric nervous system, accelerating gastric emptying and colonic transit.
Cisapride was withdrawn from the commercial market and is only available through compounding pharmacies. It remains the most effective motility agent for cats with megacolon and chronic constipation.
Cisapride was withdrawn from the human market in 2000 due to cardiac risks in human patients at high doses, but it has remained available through compounding pharmacies for veterinary use. In cats, cisapride is considered the most effective prokinetic agent available and is widely used for megacolon, chronic idiopathic constipation, and gastroparesis.
Because there is no commercial veterinary product, compounding is the only source of cisapride. Licensed compounding pharmacies prepare it as an oral suspension, typically in concentrations of 2.5mg/mL or 5mg/mL, often with flavoring for feline palatability.
Cisapride is a 5-HT4 serotonin receptor agonist. It stimulates serotonin receptors in the myenteric plexus of the gastrointestinal tract, enhancing the release of acetylcholine and increasing coordinated smooth muscle contractions throughout the GI tract — from the esophagus to the colon.
This prokinetic action accelerates gastric emptying, enhances intestinal motility, and promotes colonic transit, making it particularly effective for cats with megacolon or chronic constipation.
Cisapride is used in cats for megacolon, chronic idiopathic constipation, obstipation, and gastroparesis. It is typically used alongside dietary modification (high-fiber or low-residue diets) and stool softeners for comprehensive management of colonic motility disorders.
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⚠️ Dosing should be determined by your prescriber. The information below is general guidance only.
Cisapride is generally well tolerated in cats at recommended doses. The most common side effects are mild GI upset, diarrhea (from enhanced motility), and occasionally vomiting. The cardiac arrhythmia risk seen in humans at high doses has not been documented as a significant concern in cats at therapeutic veterinary doses.
Cisapride should not be used with drugs that inhibit CYP3A4 enzyme metabolism (e.g., ketoconazole, itraconazole), as this can increase cisapride levels.
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Prevents mast cells from degranulating — stopping the release of histamine, leukotrienes, and other inflammatory mediators before they trigger symptoms.
