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Prevents mast cells from degranulating — stopping the release of histamine, leukotrienes, and other inflammatory mediators before they trigger symptoms.
Blocks histamine H1 receptors directly at target tissues — a second line of action that manages symptoms even when some mediator release occurs.
Compounded chlorambucil capsules enable the ultra-low doses required for feline IBD and small cell lymphoma protocols — doses not achievable with commercially available 2mg tablets.
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Chlorambucil is an alkylating chemotherapy agent that interferes with DNA replication, reducing lymphocyte proliferation.
Commercial chlorambucil tablets are only available in 2mg doses, which are too large for the precise low-dose protocols used in feline IBD and lymphoma management.
Chlorambucil is an alkylating chemotherapy agent used in cats primarily for the treatment of small cell (low-grade) gastrointestinal lymphoma and inflammatory bowel disease when it has not responded to corticosteroids alone. It is typically used in combination with prednisolone as part of a "chlorambucil-pred" protocol.
The commercial formulation (Leukeran) comes only in 2mg tablets, which is often too high for the precise low-dose protocols cats require. Compounding pharmacies prepare chlorambucil in smaller doses (commonly 0.5mg–1mg capsules) that allow dose adjustments tailored to the individual patient's weight and response.
Chlorambucil is a nitrogen mustard alkylating agent that cross-links DNA strands, preventing DNA replication and cell division. It preferentially affects rapidly dividing cells, including malignant lymphocytes, making it effective against lymphoid tumors.
At the low doses used for feline IBD and small cell lymphoma, it provides immunomodulation and anti-tumor activity with a manageable side effect profile.
Chlorambucil compounded capsules are used almost exclusively in cats for small cell (low-grade) lymphoma and refractory inflammatory bowel disease, typically in combination with prednisolone. This combination ("chlorambucil-pred") is the standard of care for feline small cell lymphoma and achieves remission in a high proportion of patients.
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⚠️ Dosing should be determined by your prescriber. The information below is general guidance only.
At the low doses used for feline IBD/lymphoma, chlorambucil is generally very well tolerated. The most common side effects are mild gastrointestinal signs (vomiting, decreased appetite) and, rarely, bone marrow suppression (low blood cell counts).
Routine CBC monitoring (every 1–3 months) is recommended to detect early bone marrow suppression. Neurologic signs (tremors, seizures) are rare but possible at higher doses.
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Prevents mast cells from degranulating — stopping the release of histamine, leukotrienes, and other inflammatory mediators before they trigger symptoms.
