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Prevents mast cells from degranulating — stopping the release of histamine, leukotrienes, and other inflammatory mediators before they trigger symptoms.
Blocks histamine H1 receptors directly at target tissues — a second line of action that manages symptoms even when some mediator release occurs.
Compounded budesonide capsules for cats deliver targeted GI anti-inflammatory therapy with minimal systemic steroid effects — the preferred corticosteroid for long-term IBD management in felines.
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Budesonide is a locally-acting corticosteroid that reduces GI tract inflammation with minimal systemic absorption, lowering the risk of steroid side effects.
Commercial budesonide capsules are too large for feline dosing and contain excipients unsuitable for cats. Compounding allows precise small doses in appropriate capsule sizes.
Budesonide is a locally-acting corticosteroid with high topical activity and extensive first-pass hepatic metabolism, resulting in significantly lower systemic bioavailability compared to prednisolone. This makes it particularly valuable for long-term management of feline inflammatory bowel disease (IBD), where the goal is to reduce GI inflammation while minimizing the systemic side effects of steroid therapy.
Commercial budesonide capsules (Entocort) are formulated for human dosing (3mg), which is too large for cats. Compounding pharmacies prepare budesonide in smaller doses (commonly 0.5mg–1mg) in appropriately sized capsules that can be administered directly or opened and mixed with food.
Budesonide binds to intracellular glucocorticoid receptors in the GI mucosa, suppressing pro-inflammatory gene transcription and reducing the production of cytokines that drive intestinal inflammation. Unlike systemically absorbed corticosteroids, budesonide undergoes rapid first-pass metabolism in the liver, limiting its systemic effects to approximately 10–15% of the dose.
This results in potent local GI anti-inflammatory action with significantly reduced risk of diabetes, PU/PD, and other systemic steroid side effects.
Compounded budesonide capsules are used in cats for chronic inflammatory bowel disease (IBD), particularly as a steroid-sparing or long-term maintenance option after initial management with prednisolone. It is preferred when minimizing systemic steroid effects is a priority, such as in cats predisposed to diabetes or with concurrent conditions worsened by systemic steroids.
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⚠️ Dosing should be determined by your prescriber. The information below is general guidance only.
Budesonide has fewer systemic side effects than prednisolone, but is not entirely free of them. Some cats on long-term budesonide therapy develop mild increases in blood glucose, adrenal suppression, or weight gain. These are less severe and less frequent than with equivalent prednisolone doses.
Annual monitoring of blood glucose and adrenal function (ACTH stimulation or low-dose dexamethasone suppression) is recommended for cats on long-term therapy.
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Prevents mast cells from degranulating — stopping the release of histamine, leukotrienes, and other inflammatory mediators before they trigger symptoms.
