NSAID / Topical Anti-inflammatory Drug Class

NSAIDs (non-steroidal anti-inflammatory drugs) reduce pain and inflammation by inhibiting COX enzymes. Compounded topical NSAID formulations deliver medication directly to affected tissue, minimizing systemic side effects compared to oral NSAIDs.

How It Works

NSAIDs inhibit cyclooxygenase (COX-1 and COX-2) enzymes, blocking the conversion of arachidonic acid to prostaglandins and thromboxanes that mediate pain, swelling, and inflammation.

Why Compounded?

Topical diclofenac, ketoprofen, and piroxicam in PLO gel or DMSO bases penetrate joint and muscle tissue more effectively than commercial creams. Combinations with lidocaine, baclofen, or gabapentin for neuropathic pain require compounding.

Common Uses

Osteoarthritis and joint pain
Tendinitis and bursitis
Neuropathic pain (combination formulas)
Sports and musculoskeletal injuries
Temporomandibular joint (TMJ) disorders
Post-surgical pain management

Common Compounded Medications

Diclofenac Sodium PLO Gel
Ketoprofen Topical Cream
Ketoprofen / Lidocaine / Gabapentin Compound
Piroxicam Gel
Diclofenac / Baclofen / Cyclobenzaprine Compound

Regulatory & Safety Notes

Compounded topical NSAIDs are legal when prescribed for individual patients. The FDA has approved Voltaren (diclofenac) topical gel commercially; compounded versions offer customized bases and combination formulations. Patients with NSAID sensitivities, renal impairment, or GI issues should consult their provider.

MEDICATIONS IN THIS CLASS

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