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Ketoprofen inhibits both COX-1/COX-2 and lipoxygenase, reducing prostaglandins and leukotrienes at the application site with broader anti-inflammatory action than diclofenac.
Topical ketoprofen is not FDA-approved in the US. Compounding allows custom concentrations and multi-drug pain combinations pairing ketoprofen with gabapentin, lidocaine, and cyclobenzaprine.
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Osteoarthritis, tendinitis, muscle strains, neuropathic pain compounds
Apply 1–2g to affected area 3–4x daily
Skin irritation, photosensitivity. Lower GI risk than oral NSAIDs.
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