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VIP (Vasoactive Intestinal Peptide) is an endogenous neuropeptide with broad anti-inflammatory activity — suppressing pro-inflammatory cytokines, regulating the hypothalamic-pituitary axis, dilating pulmonary vasculature, and normalizing the innate immune dysregulation seen in CIRS and mold illness.
No FDA-approved intranasal VIP exists. Compounding pharmacies prepare VIP nasal spray as the only source for the Shoemaker Protocol's final stage — which requires VIP to complete recovery from biotoxin-associated illness.
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Vasoactive Intestinal Peptide (VIP) is a 28-amino acid neuropeptide produced throughout the nervous and immune systems. It functions as a potent anti-inflammatory signaling molecule — modulating cytokine production, regulating the hypothalamic-pituitary-adrenal axis, and controlling pulmonary vascular tone.
In the context of CIRS (Chronic Inflammatory Response Syndrome) — the biotoxin illness protocol developed by Dr. Ritchie Shoemaker — VIP nasal spray is the final treatment step after removing the patient from water-damaged environments and completing prior protocol steps. VIP addresses the hypothalamic dysregulation and cytokine patterns that persist after biotoxin exposure even after other interventions are completed.
CIRS (Chronic Inflammatory Response Syndrome) / mold illness (Shoemaker Protocol), pulmonary arterial hypertension, inflammatory bowel disease (research), MCAS adjunct, post-Lyme dysregulation
Shoemaker Protocol (intranasal): 50mcg per nostril 4x daily
Only used after all prior protocol steps are completed and patient is no longer in biotoxin exposure
Generally well tolerated. Transient flushing, mild hypotension, headache. Nausea at higher doses. VIP should not be started while in ongoing biotoxin exposure — can worsen inflammation.
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