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Vardenafil is a PDE5 inhibitor that blocks the breakdown of cGMP in penile smooth muscle, causing vasodilation and enabling erections in response to sexual stimulation. It has higher PDE5 selectivity than sildenafil, producing fewer visual side effects.
Brand Levitra and Staxyn cost $50–$80+ per pill. Compounded vardenafil provides the identical active ingredient at $2–10 per dose. Compounding also allows sublingual troches for faster onset than standard oral tablets.
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Vardenafil is a second-generation PDE5 inhibitor with higher selectivity for PDE5 over PDE6 (found in retinal tissue) compared to sildenafil — producing fewer visual disturbances such as blue-tinge and light sensitivity that some patients experience with Viagra.
Vardenafil has a similar onset to sildenafil (30–60 minutes) but some patients find it more effective at lower doses. It is available as standard oral tablets (Levitra) and dissolving oral strips (Staxyn).
Compounded vardenafil provides significant cost savings and allows sublingual troche formulations with faster onset than standard oral tablets.
PDE5 Inhibition
Vardenafil selectively inhibits PDE5, preventing cGMP degradation in penile smooth muscle. Accumulated cGMP maintains smooth muscle relaxation and vasodilation initiated by sexual stimulation and nitric oxide release.
Higher PDE5/PDE6 Selectivity
Vardenafil is approximately 15x more selective for PDE5 over PDE6 compared to sildenafil, reducing retinal PDE6 inhibition and the associated visual side effects (blue vision, photosensitivity).
Erectile Dysfunction: Primary indication — as-needed dosing 30–60 minutes before activity
Sildenafil Non-responders: Patients who don't respond adequately to sildenafil may respond to vardenafil
Visual Side Effect Sensitive: Men who experience visual disturbances with sildenafil
Standard oral: 10mg taken 30–60 minutes before sexual activity (range 5–20mg)
Sublingual troche: 5–10mg; faster onset (15–20 minutes) vs. oral tablet
Starting dose is typically 10mg. Take on an empty stomach for fastest onset — high-fat meals delay absorption. Max once daily.
Common:
Serious (rare):
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