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Semaglutide is a GLP-1 receptor agonist that mimics the hormone GLP-1, stimulating insulin secretion, suppressing glucagon, slowing gastric emptying, and reducing appetite — producing significant weight loss and blood sugar control.
Compounded semaglutide may be prescribed when a commercially available option does not meet a patient’s specific needs. Providers may consider a compounded version for: Customized dosing Flexible titration options Supply availability Cost considerations Individualized treatment plans Compounded medications are prepared by licensed pharmacies pursuant to a valid prescription and are not FDA-approved.
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Semaglutide is a GLP-1 receptor agonist originally developed for type 2 diabetes and later approved for chronic weight management. It produces some of the most significant weight loss results ever seen in a pharmaceutical — averaging 15–17% body weight reduction in clinical trials.
Compounded semaglutide became widely available when the drug was on the FDA shortage list. Following removal from the shortage list, compounding is now restricted to patients with a documented medical necessity — such as an allergy to an inactive ingredient in the commercial product or a clinical need for an alternative formulation or dose.
GLP-1 Receptor Agonism
Semaglutide binds to GLP-1 receptors in the pancreas, brain, and GI tract — stimulating glucose-dependent insulin secretion, suppressing glucagon, and activating satiety centers in the hypothalamus to reduce hunger.
Gastric Emptying
Slows stomach emptying, prolonging satiety after meals and blunting postprandial glucose spikes.
Weight Management: Chronic obesity, metabolic syndrome, BMI ≥30 or ≥27 with comorbidity
Type 2 Diabetes: Blood sugar control, HbA1c reduction
Cardiovascular: Reduction of major adverse cardiovascular events in high-risk patients
Weight management: 0.25mg/week × 4 weeks → 0.5mg → 1mg → 1.7mg → 2.4mg maintenance
Diabetes: 0.5mg/week → 1mg → 2mg
Slow titration over 16–20 weeks is critical to minimize GI side effects.
Common:
Serious (rare):
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