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Melanotan II activates melanocortin receptors (MC1R for skin tanning, MC3R/MC4R for sexual arousal and appetite suppression), stimulating melanin production in skin cells and triggering central libido and erectile enhancement pathways.
Melanotan II has no FDA-approved commercial equivalent. Compounding pharmacies prepare sterile injectable preparations as the only legitimate domestic source.
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Melanotan II (MT-II) is a synthetic analog of alpha-melanocyte-stimulating hormone (α-MSH) that activates multiple melanocortin receptors. Originally developed as a tanning agent to reduce UV-induced skin cancer risk, it was also found to produce spontaneous erections and libido enhancement in clinical trials — leading to PT-141 (bremelanotide) being developed as a more selective version for sexual dysfunction.
MT-II produces both systemic tanning and sexual enhancement effects simultaneously, which distinguishes it from PT-141 (libido-focused) and distinguishes it as a broader melanocortin agonist.
Skin tanning without UV, erectile dysfunction (especially non-responders to PDE5 inhibitors), low libido, combined sexual and cosmetic protocols
Loading (tanning): 0.5–1mg SubQ daily until desired pigmentation
Maintenance: 0.5mg 2–3x per week
Sexual function: 0.5–1mg 1–2 hours before activity
Nausea (most common — take with anti-emetic), facial flushing, spontaneous erections in men, increased mole/freckle darkness. Monitor moles — discontinue if changes noted.
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