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Glutathione is the body's master antioxidant — a tripeptide (glycine, cysteine, glutamine) that neutralizes free radicals, regenerates vitamins C and E, supports liver phase II detoxification, regulates immune function, and maintains mitochondrial integrity.
Oral glutathione is poorly absorbed and largely destroyed in the GI tract. Injectable compounded glutathione bypasses this limitation, delivering the active tripeptide directly into circulation. No commercial injectable glutathione product exists in the US, making compounding the only route for parenteral administration.
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Glutathione (GSH) is a tripeptide antioxidant produced in every cell of the body, serving as the primary endogenous defense against oxidative stress. It plays central roles in free radical neutralization, heavy metal detoxification, immune modulation, mitochondrial protection, and the recycling of other antioxidants (vitamins C and E).
Glutathione levels decline with age, chronic illness, environmental toxin exposure, and nutrient deficiencies. Depletion is implicated in neurodegenerative diseases (Parkinson's, Alzheimer's), liver disease, diabetes complications, chronic fatigue, and immune dysfunction.
Injectable compounded glutathione is widely used in functional medicine clinics, IV therapy programs, and by integrative practitioners for detoxification protocols, neurological support, skin brightening (melanin inhibition), and general antioxidant optimization.
Free Radical Scavenging
Glutathione directly neutralizes reactive oxygen species (ROS) and reactive nitrogen species (RNS), donating electrons to unstable free radicals and preventing oxidative damage to proteins, lipids, and DNA.
Phase II Liver Detoxification
Glutathione conjugates with toxins, drugs, and heavy metals in the liver via glutathione S-transferase enzymes, making them water-soluble for urinary or biliary excretion.
Tyrosinase Inhibition (Skin)
Glutathione inhibits tyrosinase — the rate-limiting enzyme in melanin synthesis — producing skin lightening/brightening effects with regular IV administration. This is a widely sought cosmetic application.
Neurological Protection
In the brain, glutathione protects dopaminergic neurons from oxidative damage. IV glutathione is used adjunctively in Parkinson's disease to reduce symptoms and slow neurodegeneration.
Detoxification: Heavy metal detox, environmental toxin clearance, liver support
Anti-aging / Longevity: Oxidative stress reduction, mitochondrial protection, cellular repair
Neurological: Parkinson's disease adjunct, cognitive protection, MS support
Skin: Skin brightening, hyperpigmentation reduction, anti-aging
Immune Support: Chronic illness, autoimmune conditions, immune optimization
IV push: 600–2400mg administered slowly over 5–15 minutes in clinic
IV infusion: 600–3000mg in saline over 30–60 minutes
IM injection: 200–600mg 2–3x per week
SubQ: 200–400mg daily or as directed
Frequency varies by indication — detox protocols may require daily dosing initially; maintenance can be weekly.
Common (generally very well tolerated):
Rare:
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