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Cyclobenzaprine reduces tonic somatic motor activity, decreasing muscle spasm and hyperreflexia. Topical application targets peripheral nerve endings with dramatically reduced central sedation.
No FDA-approved topical cyclobenzaprine exists. Compounding allows targeted muscle relaxation — commonly combined with ketoprofen, lidocaine, and gabapentin for comprehensive multi-mechanism pain relief.
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Cyclobenzaprine is a skeletal muscle relaxant widely used in multi-drug compounded pain creams. While oral cyclobenzaprine causes significant sedation, topical application provides localized muscle relaxation with minimal systemic effects — making it ideal for daytime pain management.
Back spasm, neck pain, TMJ dysfunction, shoulder pain, post-injury muscle strain. Most commonly as component of multi-drug pain cream.
Apply 1–2g to affected area 3–4x daily as part of compound
Local skin irritation. Minimal sedation with topical application.
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