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Capsaicin activates TRPV1 receptors, initially causing burning then causing reversible desensitization of nociceptors and depletion of substance P — reducing pain signal generation over time with consistent use.
OTC capsaicin tops out at 0.075%. Prescription Qutenza (8%) requires clinical administration at $1,500+. Compounding allows 0.1–5% concentrations for home use with sustained long-term treatment.
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Postherpetic neuralgia, diabetic peripheral neuropathy, CRPS, osteoarthritis joint pain, psoriasis itch
Apply 3–4x daily consistently for 2–4 weeks for therapeutic benefit. Initial burning subsides with use.
Burning and stinging at application site (expected, decreases over time). Avoid eyes and mucous membranes. Wear gloves at higher concentrations.
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