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Boric acid is a weak acid with antifungal and antibacterial properties. When inserted vaginally, it creates an acidic environment that inhibits the growth of Candida species (including azole-resistant strains like C. glabrata) and disrupts biofilms associated with bacterial vaginosis, restoring normal vaginal pH.
The standard 600mg boric acid suppository lacks a widely available FDA-approved commercial form. Compounding pharmacies have provided this preparation for decades, allowing exact 600mg dosing per ACOG guidelines in easy-to-use gelatin capsule form.
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Boric acid vaginal suppositories are recommended by ACOG and CDC guidelines for recurrent vulvovaginal candidiasis, particularly azole-resistant species. Clinical trials show 70–80% efficacy for C. glabrata infections that fail standard fluconazole treatment.
Recurrent vaginal yeast infections (especially non-albicans Candida), bacterial vaginosis (BV) adjunctive treatment, vaginal pH restoration, recurrent BV prevention.
Acute yeast infection: 600mg vaginally once daily for 14 days. Suppressive therapy: 600mg vaginally twice weekly for 6 months. BV adjunct: 600mg vaginally once daily for 21 days after antibiotic course.
Mild vaginal irritation or watery discharge (common, usually temporary). Contraindicated during pregnancy. Toxic if taken orally—vaginal use only. Do not use with open wounds or lacerations.
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