Search 7,500+ licensed pharmacies to find the best value, closest location, and fastest turnaround for
.
Baclofen is a GABA-B receptor agonist that inhibits excitatory neurotransmitter release at the spinal cord level, reducing muscle hyperexcitability, spasticity, and pain signals. Topical baclofen acts locally on peripheral GABA-B receptors with minimal systemic CNS effects.
Commercial baclofen is available only as oral tablets. Compounding allows topical gels for localized spasm relief without systemic sedation, rectal suppositories for patients unable to swallow, and precise oral liquid concentrations for pediatric or neurological titration.
Compare up to 7,500 pharmacies across the USA.
Baclofen is a centrally-acting GABA-B receptor agonist used for muscle spasticity, muscle spasm, and neuropathic pain. It is FDA-approved for spasticity associated with multiple sclerosis, spinal cord injury, and other neurological conditions.
While oral baclofen is commercially available, compounding provides formulation options that significantly expand its clinical utility: topical baclofen gels deliver localized muscle relaxation without the sedation and cognitive impairment of systemic dosing, suppositories provide a route for patients who cannot swallow medications, and custom oral concentrations allow precise pediatric dosing.
Compounded topical baclofen is particularly popular for localized conditions such as pelvic floor spasm, anal fissures, temporomandibular joint (TMJ) dysfunction, and focal muscle spasm syndromes where systemic treatment is disproportionate to the localized problem.
GABA-B Receptor Agonism
Baclofen binds to presynaptic GABA-B receptors in the spinal cord dorsal horn, reducing calcium influx and inhibiting release of excitatory neurotransmitters (glutamate, substance P). This decreases monosynaptic and polysynaptic reflex activity — reducing spasticity and pain.
Topical Peripheral Action
Topically applied baclofen acts on peripheral GABA-B receptors in muscle and nerve tissue, providing localized relaxation and pain relief with significantly less CNS penetration than oral dosing.
Neurological Spasticity: Multiple sclerosis, spinal cord injury, cerebral palsy, traumatic brain injury
Musculoskeletal: Focal muscle spasm, TMJ dysfunction, back spasm
Pelvic Floor: Pelvic floor dysfunction, vaginismus, anal fissures (topical)
Pain: Neuropathic pain, trigeminal neuralgia adjunct
Other: Alcohol use disorder (off-label), GERD (off-label)
Oral (spasticity): Start 5mg 3x daily → increase by 5mg every 3 days → typical range 40–80mg/day in divided doses
Topical gel (2–10%): Apply 1–2g to affected area 3–4x daily
Rectal suppository: 10–20mg 2–3x daily
Never stop oral baclofen abruptly — taper slowly to avoid withdrawal seizures. Topical and suppository routes do not carry the same withdrawal risk.
Oral (systemic):
Topical (much reduced):
Serious: Abrupt withdrawal of oral baclofen can cause seizures, hallucinations, and autonomic instability — always taper.
Submit a quote request to find the lowest price. Quotes delivered to your inbox.
Find Lowest Price.png){kind=spacer}
