Progestogens — primarily progesterone — prepare the uterine lining for pregnancy, balance estrogen, and support mood, sleep, and neurological health. Bioidentical progesterone is structurally identical to the progesterone the body produces naturally.
Progesterone binds to progesterone receptors and GABA-A receptors in the brain. It balances estrogen stimulation of the uterine lining, supports sleep through its conversion to allopregnanolone, and has calming, anti-anxiety neurological effects.
Commercial Prometrium is available only in oral capsules at limited doses. Compounded progesterone offers creams, suppositories, troches, and injectables at customized doses to match individual hormone levels and clinical needs.
Compounded bioidentical progesterone is legally prescribed on a patient-specific basis. FDA-approved oral progesterone (Prometrium) exists but may not suit all patients. Compounded transdermal progesterone absorption is variable and should be monitored with serum or saliva hormone testing.
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