H2 Blocker Drug Class

H2 blockers (histamine H2 receptor antagonists) reduce stomach acid by blocking H2 receptors on gastric parietal cells. In compounded form, they are used for MCAS, GERD, mastocytosis, and patients requiring customized doses or excipient-free liquid formulations.

How It Works

H2 blockers competitively inhibit histamine at H2 receptors on gastric parietal cells, reducing cyclic AMP production and decreasing gastric acid secretion by 70–95% compared to baseline.

Why Compounded?

Liquid formulations for pediatric or dysphagic patients, dye-free and preservative-free formulations, customized doses outside commercial strengths, and combinations with H1 antihistamines for MCAS protocols all require compounding.

Common Uses

MCAS (as part of H1/H2 antihistamine protocol)
GERD and acid reflux
Peptic ulcer disease
Systemic mastocytosis
Zollinger-Ellison syndrome
Pediatric acid hypersecretion

Common Compounded Medications

Famotidine Liquid (custom dose, dye-free)
Famotidine Capsules (custom strength)
Cimetidine Capsules (compounded)
Famotidine / Antacid Combination

Regulatory & Safety Notes

Famotidine (Pepcid) and cimetidine are FDA-approved and commercially available. Compounded H2 blockers are indicated when patients need preservative-free formulations, customized doses for pediatric use, or excipient-free capsules for MCAS or food sensitivity patients.

MEDICATIONS IN THIS CLASS

Browse Compounded Medications

These compounded medications belong to this drug class. Click any medication to learn more and compare pharmacy prices.

No items found.

Compare Prices for This Drug Class

Submit a free quote request and receive pricing from multiple licensed compounding pharmacies within 1–2 business days.

Get Free Quotes

Helping patients find and compare compounding pharmacies across the United States.

This information is for informational purposes only and is not meant to be a substitute for professional medical advice, diagnosis or treatment. Compounding Finder is not offering advice, recommending or endorsing any specific prescription drug, pharmacy or other information on the site. Compounding Finder provides no warranty for any information. Please seek medical advice before starting, changing or terminating any medical treatment. Compounding Finder is not sponsored by or affiliated with any of the third-party brands identified. Trademarks, brands, logos, and copyrights are the property of their respective owners.